The Adipex-PR Adipex-P Generic Name: phentermine (FEN ter meen) Brand Names: Adipex-P, Fastin, Ionamin, Obenix, Obephen, Oby-Cap, Oby-Trim, Panshape M, Phentercot, Phentride, Pro-Fast HS, Pro-Fast SA, Pro-Fast SR, Teramine, Zantryl Adipex-P is contraindicated in arteriosclerosis, cardiovascular disease, and moderate to severe hypertension. Other contraindications or adverse events include central nervous system effects, gastrointestinal disturbances, hives, and changes in libido. Exercise caution when prescribing anti-obesity drugs for patients with mild hypertension. Adipex-P is indicated as a short-term monotherapy in combination with a long-term obesity treatment program. Primary pulmonary hypertension (PPH) and cardiac valvular disease have been reported in patients receiving a combination of phentermine and fenfluramine or dexfenfluramine. The possibility of an association between PPH and the use of phentermine alone cannot be ruled out. What is the most important information I should know about Adipex? Taking Adipex together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder called pulmonary hypertension. Do not take Adipex with any other diet medications without your doctors advice. Adipex can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of Adipex. Adipex may be habit-forming and should be used only by the person it was prescribed for. Keep track of how many pills have been used from each new bottle of this medicine. Adipex is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription. You may have withdrawal symptoms, such as depression and extreme tiredness, when you stop using Adipex after using it over a long period of time. Do not stop using Adipex suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely. What is Adipex? Adipex is a stimulant that is similar to an amphetamine. Adipex is an appetite suppressant that affects the central nervous system. Adipex is used togther with diet and exercise to treat obesity (overweight) in people with risk factors such as high blood pressure, high cholesterol, or diabetes. Adipex may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking Adipex? Do not take Adipex if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take Adipex before the MAO inhibitor has cleared from your body. Taking Adipex together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder called pulmonary hypertension. Do not take Adipex with any other diet medications without your doctors advice. Do not take this medication if you are allergic to Adipex or other stimulants, or if you have: heart disease or high blood pressure; arteriosclerosis (hardening of the arteries); an overactive thyroid; glaucoma; if you are in an agitated state; or if you have a history of drug or alcohol abuse. Before taking Adipex, tell your doctor if you are allergic to any drugs, or if you have: problems with your thyroid, an anxiety disorder, epilepsy or another seizure disorder, or diabetes. If you have any of these conditions, you may not be able to use Adipex, or you may need a dosage adjustment or special tests during treatment. It is not known whether Adipex will harm an unborn baby. Do not take Adipex without first talking to your doctor if you are pregnant. It is also not known whether Adipex passes into breast milk or if it could harm a nursing baby. Do not take Adipex without first talking to your doctor if you are breast-feeding a baby. Do not give this medication to anyone younger than 16 years old without the advice of a doctor. How should I take Adipex? Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Taking high doses of Adipex over long periods of time can cause severe skin problems, sleep problems (insomnia), personality changes, and feeling hyperactive or irritable. Take this medicine with a full glass of water. It is best to take Adipex on an empty stomach before breakfast, or at least 10 to 14 hours before bedtime. Adipex should be taken only for a short time, such as a few weeks. Do not crush, chew, break, or open an extended-release capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. You may have withdrawal symptoms when you stop using Adipex after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely. Do not take Adipex in the evening because it may cause sleep problems (insomnia). Stop taking Adipex if you have increased hunger or if you otherwise think the medication is not working properly. Do not take more Adipex for an increased effect. Taking too much of this medication can cause serious, life-threatening side effects. Adipex may be habit-forming and should be used only by the person it was prescribed for. Keep track of how many pills have been used from each new bottle of this medicine. Adipex is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription. Store Adipex at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medication. An overdose of Adipex can be fatal. Symptoms of a Adipex overdose may include confusion, hallucinations, feeling restless or aggressive, nausea, vomiting, diarrhea, stomach pain, irregular heartbeat, tremors, rapid breathing, confusion, hallucinations, feeling light-headed, fainting, or seizure (convulsions). What should I avoid while taking Adipex? Avoid drinking alcohol. It can increase some of the side effects of Adipex. Adipex can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. What are the possible side effects of Adipex? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Adipex and call your doctor at once if you have any of these serious side effects: chest pain, swelling in your ankles or feet, feeling light-headed, fainting, or feeling short of breath, even with mild exertion; fast or uneven heartbeat; unusual thoughts or behavior, feeling restless or confused; or increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure). Less serious side effects may be more likely to occur, such as: feeling nervous or anxious; headache, dizziness, tremors; trouble sleeping (insomnia); dry mouth or an unpleasant taste in your mouth; diarrhea or constipation; or itching. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect Adipex? Before taking Adipex, tell your doctor if you are using any of the following drugs: medicines to treat high blood pressure; insulin or diabetes medication you take by mouth; guanadrel (Hylorel), guanethidine (Ismelin); antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft); or antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil). If you are using any of these drugs, you may not be able to use Adipex, or you may need dosage adjustments or special tests during treatment. There may be other drugs not listed that can affect Adipex. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Where can I get more information? Your pharmacist has information about Adipex written for health professionals that you may read. What does my medication look like? Phentermine is available with a prescription under the brand names Adipex and Fastin. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you. Adipex-P 37.5 mg white, oblong, scored tablets with blue speckles Adipex-P 37.5 mg light-blue-and-white capsules with two blue bands Fastin 30 mg blue-and-clear capsules with blue and white beads Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2006 Cerner Multum, Inc. Version: 4.02. 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